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Based on results from second-line therapy and the established safety profile of tamoxifen.the incidences of 9 pre-specified adverse event categories potentially causally related to one or both of the therapies because of their pharmacology were statistically analyzed. Nosignificant differences were seen between treatment groups.

Patients receiving ARIMIDEX had a lower incidence of hot flashes.vaginal bleeding.vaginal discharge.endometrial cancer.venous thromboembolic events and ischemic cerebrovascular events compared with patients receiving tamoxifen.

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